Version 5.4
Homo sapiens Gene: HIST2H4A
Summary
InnateDB Gene IDBG-772788.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST2H4A
Gene Name histone cluster 2, H4a
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000270882
Encoded Proteins
IDBP-807066
histone cluster 2, H4a
IDBP-807068
histone cluster 2, H4a
IDBP-807069
histone cluster 2, H4a
IDBP-807070
histone cluster 2, H4a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:149832659-149839767
Strand Forward strand
Band q21.2
Transcripts
ENST00000578186 ENSP00000462667
ENST00000618193 ENSP00000478786
ENST00000614272 ENSP00000478519
ENST00000613412 ENSP00000481343
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
Experimentally validated
Total 47 [view]
Protein-Protein 45 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0035575 histone demethylase activity (H4-K20 specific)
GO:0044822 poly(A) RNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000278 mitotic cell cycle
GO:0000723 telomere maintenance
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006335 DNA replication-dependent nucleosome assembly
GO:0006336 DNA replication-independent nucleosome assembly
GO:0006352 DNA-templated transcription, initiation
GO:0034080 centromere-specific nucleosome assembly
GO:0035574 histone H4-K20 demethylation
GO:0045653 negative regulation of megakaryocyte differentiation
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0000228 nuclear chromosome
GO:0000786 nucleosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa05322
Systemic lupus erythematosus pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B2R4R0 Q6B823
UniProt Splice Variant
Entrez Gene 8370
UniGene
RefSeq NM_003548
HUGO HGNC:4794
OMIM 142750 602822 602823 602824 602825 602826 602827 602828 602829 602830 602831 602833 615069
CCDS CCDS30847
HPRD
IMGT
EMBL AB000905 AB451459 AF525682 AK311916 AK312028 AK312153 AK316561 AL021807 AL021917 AL031777 AL049822 AL353759 AL591493 AY128653 AY128654 AY128655 AY128656 AY128657 AY128658 AY128659 AY128661 AY128662 AY128663 AY128664 AY128665 AY648850 AY675271 AY675295 BC017361 BC054014 BC066248 BC066249 BC066250 BC067495 BC067496 BC067497 BC069288 BC069392 BC069467 BC069654 BC093763 BC093765 BC093969 BC111093 BC111434 BC112193 BC120939 BC128104 BC128105 BC130558 BC130560 BC143045 BC148271 CH471081 CH471087 CH471094 CR542169 CR542172 CR542180 CR542187 CR542189 M16707 M60749 X00038 X60481 X60482 X60483 X60484 X60486 X60487 X67081 X83548 Z80787 Z98744
GenPept AAA52652 AAA63188 AAH17361 AAH54014 AAH66248 AAH66249 AAH66250 AAH67495 AAH67496 AAH67497 AAH69288 AAH69392 AAH69467 AAH69654 AAH93763 AAH93765 AAH93969 AAI11094 AAI11435 AAI12194 AAI20940 AAI28105 AAI28106 AAI30559 AAI30561 AAI43046 AAI48272 AAM83108 AAN01438 AAN01439 AAN01440 AAN01441 AAN01442 AAN01443 AAN01444 AAN01446 AAN01447 AAN01448 AAN01449 AAN01450 AAT68253 AAT78448 AAT78472 BAA19208 BAG34857 BAG34965 BAG35087 BAG38150 BAG70273 CAA16946 CAA24918 CAA43011 CAA43012 CAA43013 CAA43014 CAA43016 CAA43017 CAA47464 CAA58538 CAB02549 CAC03414 CAC03418 CAC03426 CAC03427 CAC04128 CAC69642 CAD24074 CAG46966 CAG46969 CAG46977 CAG46984 CAG46986 CAI12560 CAI12567 EAW55509 EAW55510 EAW55538 EAW55549 EAW55555 EAW55556 EAW96325 EAX03086 EAX03111 EAX03112 EAX03121
RNA Seq Atlas 121504 554313 8294 8359 8360 8361 8362 8363 8364 8365 8366 8367 8368 8370

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca