Version 5.4
Homo sapiens Gene: TTYH1
Summary
InnateDB Gene IDBG-68627.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTYH1
Gene Name tweety homolog 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167614
Encoded Proteins
IDBP-68629
tweety homolog 1 (Drosophila)
IDBP-68631
tweety homolog 1 (Drosophila)
IDBP-68633
tweety homolog 1 (Drosophila)
IDBP-247085
tweety homolog 1 (Drosophila)
IDBP-384902
tweety homolog 1 (Drosophila)
IDBP-384910
tweety homolog 1 (Drosophila)
IDBP-384912
tweety homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-) channel. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:54415219-54436900
Strand Forward strand
Band q13.42
Transcripts
ENST00000301194 ENSP00000301194
ENST00000376531 ENSP00000365714
ENST00000376530 ENSP00000365713
ENST00000391739 ENSP00000375619
ENST00000423529 ENSP00000391282
ENST00000445095 ENSP00000393592
ENST00000425969 ENSP00000402817
ENST00000487134
ENST00000462757
ENST00000462769
ENST00000478036
ENST00000461302
ENST00000476757
ENST00000489425
ENST00000492920
ENST00000476863
ENST00000467939
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005254 chloride channel activity
GO:0005381 iron ion transmembrane transporter activity
GO:0005509 calcium ion binding
GO:0072320 volume-sensitive chloride channel activity
Biological Process
GO:0006821 chloride transport
GO:0006826 iron ion transport
GO:0007067 mitotic nuclear division
GO:0016337 single organismal cell-cell adhesion
GO:0031589 cell-substrate adhesion
GO:0034220 ion transmembrane transport
GO:0034755 iron ion transmembrane transport
GO:0044070 regulation of anion transport
GO:0046847 filopodium assembly
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030868 smooth endoplasmic reticulum membrane
GO:0031527 filopodium membrane
GO:0032433 filopodium tip
GO:0034707 chloride channel complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030428
View Gene Order
ENSBTAG00000003470
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.268728
RefSeq NM_001005367 NM_001201461 NM_020659
HUGO
OMIM
CCDS CCDS12893 CCDS33106 CCDS56102
HPRD 12043
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca