InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ABCA7

Summary

InnateDB Gene

IDBG-645574.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCA7

Gene Name

ATP-binding cassette sub-family A member 7

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020766

Encoded Proteins

IDBP-698304

ATP-binding cassette, sub-family A (ABC1), member 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000064687:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:45165707-45182208

Strand

Forward strand

Band

Transcripts

ENSBTAT00000020083

ENSBTAP00000020083

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0005548	phospholipid transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0034188	apolipoprotein A-I receptor activity

Biological Process

GO:0006200	ATP catabolic process
GO:0008152	metabolic process
GO:0017121	phospholipid scrambling
GO:0032780	negative regulation of ATPase activity
GO:0032781	positive regulation of ATPase activity
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034380	high-density lipoprotein particle assembly
GO:0038027	apolipoprotein A-I-mediated signaling pathway