Version 5.4
Bos taurus Gene: PQBP1
Summary
InnateDB Gene IDBG-636936.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PQBP1
Gene Name Polyglutamine-binding protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018498
Encoded Proteins
IDBP-688910
Polyglutamine-binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26046437
[Homo sapiens] PQBP1 directly binds to reverse-transcribed HIV-1 DNA and interacts with MB21D1 to initiate an IRF3-dependent innate response.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102103:
This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:92092355-92098095
Strand Forward strand
Band
Transcripts
ENSBTAT00000024621 ENSBTAP00000024621
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0000380 alternative mRNA splicing, via spliceosome
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0031175 neuron projection development
GO:0034063 stress granule assembly
GO:0043484 regulation of RNA splicing
GO:0048814 regulation of dendrite morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0010494 cytoplasmic stress granule
GO:0016607 nuclear speck
GO:0071598 neuronal ribonucleoprotein granule
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000102103
View Gene Order
ENSMUSG00000031157
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03040
Spliceosome pathway
mmu03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt Q2HJC9
TrEMBL
UniProt Splice Variant
Entrez Gene 534894
UniGene Bt.13598
RefSeq NM_001046389
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105573
GenPept AAI05574
RNA Seq Atlas 534894

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca