Version 5.4
Homo sapiens Gene: ABCG5
Summary
InnateDB Gene IDBG-49230.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCG5
Gene Name ATP-binding cassette, sub-family G (WHITE), member 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138075
Encoded Proteins
IDBP-49232
ATP-binding cassette, sub-family G (WHITE), member 5
IDBP-293750
ATP-binding cassette, sub-family G (WHITE), member 5
IDBP-293747
ATP-binding cassette, sub-family G (WHITE), member 5
IDBP-482347
ATP-binding cassette, sub-family G (WHITE), member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:43812472-43838865
Strand Reverse strand
Band p21
Transcripts
ENST00000260645 ENSP00000260645
ENST00000405322 ENSP00000384513
ENST00000409962 ENSP00000386501
ENST00000486512 ENSP00000430935
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0017127 cholesterol transporter activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006200 ATP catabolic process
GO:0007584 response to nutrient
GO:0007588 excretion
GO:0010212 response to ionizing radiation
GO:0010949 negative regulation of intestinal phytosterol absorption
GO:0015918 sterol transport
GO:0030299 intestinal cholesterol absorption
GO:0033344 cholesterol efflux
GO:0042493 response to drug
GO:0042632 cholesterol homeostasis
GO:0044281 small molecule metabolic process
GO:0045796 negative regulation of intestinal cholesterol absorption
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040505
View Gene Order
ENSBTAG00000016365
Not yet available
Pathways
NETPATH
REACTOME
REACT_111158
ABCA transporters in lipid homeostasis pathway
REACT_15480
ABC-family proteins mediated transport pathway
REACT_13781
Trafficking of dietary sterols pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
KEGG
hsa02010
ABC transporters pathway
hsa04975
Fat digestion and absorption pathway
hsa04976
Bile secretion pathway
INOH
PID NCI
Cross-References
SwissProt Q9H222
TrEMBL Q2T9G2 Q53QN9 Q53T83
UniProt Splice Variant
Entrez Gene 64240
UniGene Hs.132992
RefSeq NM_022436
HUGO HGNC:13886
OMIM 605459
CCDS CCDS1814
HPRD 05678
IMGT
EMBL AC011242 AC108476 AF312715 AF320293 AF404106 AF404107 BC111541 CH471053
GenPept AAG40003 AAG53099 AAI11542 AAK85387 AAK85388 AAY14703 AAY24010 EAX00286
RNA Seq Atlas 64240

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca