Version 5.4
Homo sapiens Gene: CDKL5
Summary
InnateDB Gene IDBG-48621.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDKL5
Gene Name cyclin-dependent kinase-like 5
Synonyms EIEE2; ISSX; STK9
Species Homo sapiens
Ensembl Gene ENSG00000008086
Encoded Proteins
IDBP-48623
cyclin-dependent kinase-like 5
IDBP-48627
cyclin-dependent kinase-like 5
IDBP-809736
cyclin-dependent kinase-like 5
IDBP-809731
cyclin-dependent kinase-like 5
IDBP-809733
cyclin-dependent kinase-like 5
IDBP-809734
cyclin-dependent kinase-like 5
IDBP-809747
cyclin-dependent kinase-like 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:18425583-18653629
Strand Forward strand
Band p22.13
Transcripts
ENST00000379996 ENSP00000369332
ENST00000379989 ENSP00000369325
ENST00000463994 ENSP00000485184
ENST00000624953 ENSP00000485625
ENST00000623364 ENSP00000485581
ENST00000624700 ENSP00000485359
ENST00000623535 ENSP00000485244
ENST00000623610
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0048365 Rac GTPase binding
Biological Process
GO:0001764 neuron migration
GO:0006468 protein phosphorylation
GO:0032855 positive regulation of Rac GTPase activity
GO:0045773 positive regulation of axon extension
GO:0046777 protein autophosphorylation
GO:0050773 regulation of dendrite development
GO:0050775 positive regulation of dendrite morphogenesis
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0032587 ruffle membrane
GO:0032839 dendrite cytoplasm
GO:0044294 dendritic growth cone
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031292
View Gene Order
ENSBTAG00000007428
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.659851
RefSeq NM_001037343 NM_003159 XM_006724511
HUGO
OMIM
CCDS CCDS14186
HPRD 02190
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca