Homo sapiens Gene: CYP4F8
Summary
InnateDB Gene IDBG-34835.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP4F8
Gene Name cytochrome P450, family 4, subfamily F, polypeptide 8
Synonyms CPF8; CYPIVF8
Species Homo sapiens
Ensembl Gene ENSG00000186526
Encoded Proteins
cytochrome P450, family 4, subfamily F, polypeptide 8
cytochrome P450, family 4, subfamily F, polypeptide 8
cytochrome P450, family 4, subfamily F, polypeptide 8
cytochrome P450, family 4, subfamily F, polypeptide 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandins in seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is approximately 18 kb away. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:15615218-15630638
Strand Forward strand
Band p13.12
Transcripts
ENST00000325723 ENSP00000479430
ENST00000441682
ENST00000589722 ENSP00000482692
ENST00000589778
ENST00000590745
ENST00000589927
ENST00000587680
ENST00000585349
ENST00000590209
ENST00000617645 ENSP00000478555
ENST00000622291
ENST00000612078 ENSP00000477567
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018685 alkane 1-monooxygenase activity
GO:0020037 heme binding
GO:0070330 aromatase activity
Biological Process
GO:0006690 icosanoid metabolic process
GO:0006693 prostaglandin metabolic process
GO:0006805 xenobiotic metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
Arachidonic acid metabolism pathway
Fatty acids pathway
Eicosanoids pathway
Metabolism of lipids and lipoproteins pathway
Cytochrome P450 - arranged by substrate type pathway
Metabolism pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Arachidonic acid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.268554
RefSeq NM_007253
HUGO
OMIM
CCDS CCDS74303
HPRD 08518
IMGT
EMBL
GenPept
RNA Seq Atlas