Version 5.4
Homo sapiens Gene: MAN2A2
Summary
InnateDB Gene IDBG-30540.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAN2A2
Gene Name mannosidase, alpha, class 2A, member 2
Synonyms MANA2X
Species Homo sapiens
Ensembl Gene ENSG00000196547
Encoded Proteins
IDBP-30542
mannosidase, alpha, class 2A, member 2
IDBP-594236
mannosidase, alpha, class 2A, member 2
IDBP-588013
mannosidase, alpha, class 2A, member 2
IDBP-600374
mannosidase, alpha, class 2A, member 2
IDBP-589901
mannosidase, alpha, class 2A, member 2
IDBP-586585
mannosidase, alpha, class 2A, member 2
IDBP-590114
mannosidase, alpha, class 2A, member 2
IDBP-600356
mannosidase, alpha, class 2A, member 2
IDBP-584242
mannosidase, alpha, class 2A, member 2
IDBP-583353
mannosidase, alpha, class 2A, member 2
IDBP-600755
mannosidase, alpha, class 2A, member 2
IDBP-600671
mannosidase, alpha, class 2A, member 2
IDBP-601239
mannosidase, alpha, class 2A, member 2
IDBP-601348
mannosidase, alpha, class 2A, member 2
IDBP-601321
mannosidase, alpha, class 2A, member 2
IDBP-601462
mannosidase, alpha, class 2A, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 15:90902218-90922584
Strand Forward strand
Band q26.1
Transcripts
ENST00000360468 ENSP00000353655
ENST00000558290 ENSP00000453740
ENST00000558853 ENSP00000452691
ENST00000559999 ENSP00000453078
ENST00000560534
ENST00000560451 ENSP00000453999
ENST00000558161 ENSP00000452631
ENST00000559717 ENSP00000452948
ENST00000559965 ENSP00000453956
ENST00000560192
ENST00000559132 ENSP00000452897
ENST00000558640
ENST00000561046
ENST00000557865 ENSP00000453140
ENST00000560616 ENSP00000452866
ENST00000558171 ENSP00000452928
ENST00000561240
ENST00000560505
ENST00000559374
ENST00000561047
ENST00000561448 ENSP00000452813
ENST00000560147 ENSP00000453253
ENST00000557990 ENSP00000453341
ENST00000558538
ENST00000559341
ENST00000560926
ENST00000560880
ENST00000558374
ENST00000559558
ENST00000559704 ENSP00000453659
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004559 alpha-mannosidase activity
GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
GO:0008270 zinc ion binding
GO:0015923 mannosidase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006013 mannose metabolic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038886
View Gene Order
ENSBTAG00000018905
Not yet available
Pathways
NETPATH
REACTOME
REACT_25302
Reactions specific to the complex N-glycan synthesis pathway pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_25208
N-glycan antennae elongation in the medial/trans-Golgi pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.116459 Hs.733174 Hs.735877 Hs.738557
RefSeq NM_006122 XM_005254911
HUGO
OMIM
CCDS CCDS32332
HPRD 02994
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca