Version 5.4
Homo sapiens Gene: PDS5B
Summary
InnateDB Gene IDBG-23233.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDS5B
Gene Name PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
Synonyms APRIN; AS3; CG008
Species Homo sapiens
Ensembl Gene ENSG00000083642
Encoded Proteins
IDBP-23235
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
IDBP-364224
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
IDBP-364229
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that interacts with the conserved protein complex termed cohesion. The cohesion complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:32586427-32778019
Strand Forward strand
Band q13.1
Transcripts
ENST00000315596 ENSP00000313851
ENST00000450460 ENSP00000401619
ENST00000447833 ENSP00000407005
ENST00000482955
ENST00000498550
ENST00000493653
ENST00000466078
ENST00000481616
ENST00000474274
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007064 mitotic sister chromatid cohesion
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0042127 regulation of cell proliferation
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034021
View Gene Order
ENSBTAG00000011597
Not yet available
Pathways
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_150421
Cohesin Loading onto Chromatin pathway
REACT_1932
Mitotic Telophase/Cytokinesis pathway
REACT_150266
Establishment of Sister Chromatid Cohesion pathway
REACT_899
S Phase pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A9IYQ1
UniProt Splice Variant
Entrez Gene 23047
UniGene Hs.646051 Hs.729956
RefSeq NM_015032 XM_005266295 XM_005266296 XM_005266298
HUGO HGNC:20418
OMIM 605333
CCDS CCDS41878
HPRD 05624
IMGT
EMBL AL138820 Z75889 Z84467 Z84572
GenPept
RNA Seq Atlas 23047

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca