InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Iapp

Summary

InnateDB Gene

IDBG-196723.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Iapp

Gene Name

islet amyloid polypeptide

Synonyms

DAP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041681

Encoded Proteins

IDBP-196725

islet amyloid polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121351:
Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. [provided by RefSeq, Apr 2011]
The protein encoded by this gene is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer\'s disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:142298423-142303961

Strand

Forward strand

Band

Transcripts

ENSMUST00000041993	ENSMUSP00000043956
ENSMUST00000141583

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0042802	identical protein binding

Biological Process

GO:0019233	sensory perception of pain
GO:0031018	endocrine pancreas development
GO:0042755	eating behavior
GO:0045596	negative regulation of cell differentiation
GO:0045779	negative regulation of bone resorption