InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cd47

Summary

InnateDB Gene

IDBG-165137.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd47

Gene Name

CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

Synonyms

9130415E20Rik; AA407862; AI848868; AW108519; B430305P08Rik; IAP; Itgp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000055447

Encoded Proteins

IDBP-165139

CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

IDBP-251634

CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26010544

Cd47 plays a protective role against disseminated candidiasis and alters pro-inflammatory and immunosuppressive pathways known to regulate innate and T cell immunity.

PMID 27194758

Cd47 plays a role as a negative regulator in inducing protective immune responses to influenza vaccination.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196776:
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:49855618-49915010

Strand

Forward strand

Band

Transcripts

ENSMUST00000084838	ENSMUSP00000099853
ENSMUST00000114496	ENSMUSP00000110140

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0070053	thrombospondin receptor activity

Biological Process

GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0008228	opsonization
GO:0008284	positive regulation of cell proliferation
GO:0009617	response to bacterium
GO:0022409	positive regulation of cell-cell adhesion
GO:0045087	innate immune response (InnateDB)
GO:0050729	positive regulation of inflammatory response
GO:0050766	positive regulation of phagocytosis
GO:0050870	positive regulation of T cell activation