Version 5.4
Mus musculus Gene: Upb1
Summary
InnateDB Gene IDBG-162710.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Upb1
Gene Name ureidopropionase, beta
Synonyms AI195023
Species Mus musculus
Ensembl Gene ENSMUSG00000033427
Encoded Proteins
IDBP-162712
ureidopropionase, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that catalyzes the conversion of N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to beta-aminoisobutyric acid or beta-alanine. Mutations in the related gene in human have been associated with beta-ureidopropionase deficiency. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:75406911-75441679
Strand Forward strand
Band C1
Transcripts
ENSMUST00000039925 ENSMUSP00000049342
ENSMUST00000138058
ENSMUST00000132629
ENSMUST00000129946
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003837 beta-ureidopropionase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0046872 metal ion binding
Biological Process
GO:0006807 nitrogen compound metabolic process
GO:0019483 beta-alanine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100024
View Gene Order
ENSBTAG00000001325
Not yet available
Pathways
NETPATH
REACTOME
REACT_236186
Pyrimidine metabolism pathway
REACT_188937
Metabolism pathway
REACT_241108
Pyrimidine catabolism pathway
REACT_245662
Metabolism of nucleotides pathway
KEGG
mmu00410
beta-Alanine metabolism pathway
mmu00240
Pyrimidine metabolism pathway
mmu00770
Pantothenate and CoA biosynthesis pathway
mmu00983
Drug metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1023
Pyrimidine catabolism pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_957
Pyrimidine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00770
Pantothenate and CoA biosynthesis pathway
hsa00410
beta-Alanine metabolism pathway
hsa00983
Drug metabolism pathway
INOH
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt Q8VC97
TrEMBL Q3UEK4
UniProt Splice Variant
Entrez Gene 103149
UniGene Mm.441195
RefSeq NM_133995
OMIM
CCDS CCDS23925
HPRD
IMGT
MGI ID MGI:2143535
MGI Symbol Upb1
EMBL AK149373 AK149480 BC021388 BC024447 CH466553
GenPept AAH21388 AAH24447 BAE28841 BAE28907 EDL31923
RNA Seq Atlas 103149

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca