Version 5.4
Homo sapiens Gene: GNPDA2
Summary
InnateDB Gene IDBG-16240.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNPDA2
Gene Name glucosamine-6-phosphate deaminase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163281
Encoded Proteins
IDBP-16244
glucosamine-6-phosphate deaminase 2
IDBP-480761
glucosamine-6-phosphate deaminase 2
IDBP-485354
glucosamine-6-phosphate deaminase 2
IDBP-475617
glucosamine-6-phosphate deaminase 2
IDBP-811064
glucosamine-6-phosphate deaminase 2
IDBP-811066
glucosamine-6-phosphate deaminase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:44682200-44726595
Strand Reverse strand
Band p12
Transcripts
ENST00000295448 ENSP00000295448
ENST00000507917 ENSP00000425868
ENST00000507534 ENSP00000427423
ENST00000509756 ENSP00000424061
ENST00000511187
ENST00000608855 ENSP00000477137
ENST00000609092 ENSP00000476853
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004342 glucosamine-6-phosphate deaminase activity
GO:0016787 hydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006044 N-acetylglucosamine metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029209
View Gene Order
ENSBTAG00000000287
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.21398 Hs.594601 Hs.597934 Hs.741325
RefSeq NM_001270880 NM_001270881 NM_138335 XM_005248053
HUGO
OMIM
CCDS CCDS3469 CCDS59472 CCDS59473
HPRD 13594
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca