Version 5.4
Mus musculus Gene: Loxhd1
Summary
InnateDB Gene IDBG-159725.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Loxhd1
Gene Name lipoxygenase homology domains 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000032818
Encoded Proteins
IDBP-159727
lipoxygenase homology domains 1
IDBP-159729
lipoxygenase homology domains 1
IDBP-536763
lipoxygenase homology domains 1
IDBP-540271
lipoxygenase homology domains 1
IDBP-536336
lipoxygenase homology domains 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167210:
This gene encodes a highly conserved protein consisting entirely of PLAT (polycystin/lipoxygenase/alpha-toxin) domains, thought to be involved in targeting proteins to the plasma membrane. Studies in mice show that this gene is expressed in the mechanosensory hair cells in the inner ear, and mutations in this gene lead to auditory defects, indicating that this gene is essential for normal hair cell function. Screening of human families segregating deafness identified a mutation in this gene which causes DFNB77, a progressive form of autosomal-recessive nonsyndromic hearing loss (ARNSHL). Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:77281958-77442341
Strand Forward strand
Band E3
Transcripts
ENSMUST00000035501 ENSMUSP00000045450
ENSMUST00000096547 ENSMUSP00000094294
ENSMUST00000148341 ENSMUSP00000114988
ENSMUST00000123410 ENSMUSP00000120991
ENSMUST00000123166 ENSMUSP00000116287
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005262 calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0007605 sensory perception of sound
GO:0050982 detection of mechanical stimulus
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0032420 stereocilium
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167210
View Gene Order
ENSBTAG00000015210
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.380247
RefSeq NM_172834 XM_006526434
OMIM
CCDS CCDS50326
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca