Version 5.4
Mus musculus Gene: Hibch
Summary
InnateDB Gene IDBG-153761.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hibch
Gene Name 3-hydroxyisobutyryl-Coenzyme A hydrolase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000041426
Encoded Proteins
IDBP-153763
3-hydroxyisobutyryl-Coenzyme A hydrolase
IDBP-541597
3-hydroxyisobutyryl-Coenzyme A hydrolase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198130:
This gene encodes the enzyme responsible for hydrolysis of both HIBYL-CoA and beta-hydroxypropionyl-CoA. Mutations in this gene have been associated with 3-hyroxyisobutyryl-CoA hydrolase deficiency. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:52844929-52920986
Strand Forward strand
Band C1.1
Transcripts
ENSMUST00000044478 ENSMUSP00000045606
ENSMUST00000159352 ENSMUSP00000124976
ENSMUST00000161125
ENSMUST00000161552
ENSMUST00000159431
ENSMUST00000162609
ENSMUST00000186922
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity
Biological Process
GO:0006574 valine catabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198130
View Gene Order
ENSBTAG00000007787
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_254568
Branched-chain amino acid catabolism pathway
KEGG
mmu00410
beta-Alanine metabolism pathway
mmu00280
Valine, leucine and isoleucine degradation pathway
mmu00640
Propanoate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_197
Branched-chain amino acid catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00280
Valine, leucine and isoleucine degradation pathway
hsa00640
Propanoate metabolism pathway
hsa00410
beta-Alanine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_146108
OMIM
CCDS CCDS14948
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca