InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tbxas1

Summary

InnateDB Gene

IDBG-137700.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tbxas1

Gene Name

thromboxane A synthase 1, platelet

Synonyms

CYP5; CYP5A1; THAS; TS; TXAS; TXS

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029925

Encoded Proteins

IDBP-137702

thromboxane A synthase 1, platelet

IDBP-532267

thromboxane A synthase 1, platelet

IDBP-539901

thromboxane A synthase 1, platelet

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000059377:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:38875404-39084585

Strand

Forward strand

Band

Transcripts

ENSMUST00000003017	ENSMUSP00000003017
ENSMUST00000162521	ENSMUSP00000125406
ENSMUST00000159226
ENSMUST00000161781
ENSMUST00000160963	ENSMUSP00000124640
ENSMUST00000162656
ENSMUST00000161360

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0004796	thromboxane-A synthase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0030644	cellular chloride ion homeostasis
GO:0045907	positive regulation of vasoconstriction
GO:0055114	oxidation-reduction process