InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mmp16

Summary

InnateDB Gene

IDBG-130811.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mmp16

Gene Name

matrix metallopeptidase 16

Synonyms

MT3-MMP; Mt3mmp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028226

Encoded Proteins

IDBP-130813

matrix metallopeptidase 16

IDBP-539076

matrix metallopeptidase 16

IDBP-538453

matrix metallopeptidase 16

IDBP-787530

matrix metallopeptidase 16

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156103:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:17852893-18119145

Strand

Forward strand

Band

Transcripts

ENSMUST00000029881	ENSMUSP00000029881
ENSMUST00000142434	ENSMUSP00000121087
ENSMUST00000133416
ENSMUST00000149353	ENSMUSP00000116930
ENSMUST00000139418
ENSMUST00000183662	ENSMUSP00000139102

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001503	ossification
GO:0001958	endochondral ossification
GO:0006508	proteolysis
GO:0030574	collagen catabolic process
GO:0035988	chondrocyte proliferation
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0060348	bone development
GO:0097094	craniofacial suture morphogenesis

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0031012	extracellular matrix

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000156103

View Gene Order

ENSBTAG00000006877

Not yet available

Pathways

NETPATH

REACTOME

REACT_199000

Activation of Matrix Metalloproteinases pathway

REACT_206066

Extracellular matrix organization pathway

REACT_199052

Degradation of the extracellular matrix pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_118682

Activation of Matrix Metalloproteinases pathway

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.187315 Mm.402838 Mm.406849 Mm.411943 Mm.452968 Mm.487950

RefSeq

NM_019724 XM_006537641

OMIM

CCDS

CCDS17989

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas