Version 5.4
Homo sapiens Gene: SLC35A3
Summary
InnateDB Gene IDBG-100468.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC35A3
Gene Name solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
Synonyms AMRS
Species Homo sapiens
Ensembl Gene ENSG00000117620
Encoded Proteins
IDBP-100472
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
IDBP-100474
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
IDBP-387155
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
IDBP-387156
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
IDBP-485544
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
IDBP-590470
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
IDBP-585783
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a UDP-N-acetylglucosamine transporter found in the golgi apparatus membrane. In cattle, a missense mutation in this gene causes complex vertebral malformation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:99969789-100026979
Strand Forward strand
Band p21.2
Transcripts
ENST00000370156
ENST00000370155 ENSP00000359174
ENST00000370153 ENSP00000359172
ENST00000427993 ENSP00000414947
ENST00000422078 ENSP00000401679
ENST00000465289 ENSP00000418527
ENST00000533028 ENSP00000433849
ENST00000532693 ENSP00000436938
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005338 nucleotide-sugar transmembrane transporter activity
GO:0005351 sugar:proton symporter activity
GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity
GO:0005515 protein binding
Biological Process
GO:0006047 UDP-N-acetylglucosamine metabolic process
GO:0008643 carbohydrate transport
GO:0015780 nucleotide-sugar transport
GO:0015788 UDP-N-acetylglucosamine transport
GO:0015992 proton transport
GO:0055085 transmembrane transport
GO:1901679 nucleotide transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027957
View Gene Order
ENSBTAG00000012454
Not yet available
Pathways
NETPATH
REACTOME
REACT_22151
Transport of nucleotide sugars pathway
REACT_22285
Transport of vitamins, nucleosides, and related molecules pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.448979 Hs.598077 Hs.603153 Hs.617357
RefSeq NM_001271684 NM_001271685 NM_012243 XM_005270691 XM_005270693
HUGO
OMIM
CCDS CCDS60204 CCDS60205 CCDS762
HPRD 10413
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca