InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LPHN2

Summary

InnateDB Protein

IDBP-99895.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPHN2

Protein Name

latrophilin 2

Synonyms

CIRL2; CL2; LEC1; LPHH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000359758

InnateDB Gene

IDBG-99887 (LPHN2)

Protein Structure

UniProt Annotation

Function

Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others. {ECO:0000269PubMed:10030676}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016524	latrotoxin receptor activity
GO:0030246	carbohydrate binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000203 GPS motif
IPR000832 GPCR, family 2, secretin-like
IPR000922 D-galactoside/L-rhamnose binding SUEL lectin domain
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR003112 Olfactomedin-like
IPR003334 GPCR, family 2, latrophilin, C-terminal
IPR003924 GPCR, family 2, latrophilin
IPR017981 GPCR, family 2-like
IPR022624 Domain of unknown function DUF3497

PFAM