InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNCG

Summary

InnateDB Protein

IDBP-81149.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNCG

Protein Name

synuclein, gamma (breast cancer-specific protein 1)

Synonyms

BCSG1; SR;

Species

Homo sapiens

Ensembl Protein

ENSP00000361087

InnateDB Gene

IDBG-81145 (SNCG)

Protein Structure

UniProt Annotation

Function

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:11746666}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:11746666}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:11746666}. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.

Disease Associations

Tissue Specificity

Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043014	alpha-tubulin binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0002118	aggressive behavior
GO:0007268	synaptic transmission
GO:0008344	adult locomotory behavior
GO:0009306	protein secretion
GO:0014059	regulation of dopamine secretion
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0046928	regulation of neurotransmitter secretion
GO:0050808	synapse organization
GO:0071464	cellular response to hydrostatic pressure

Cellular Component

GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005819	spindle
GO:0005886	plasma membrane
GO:0030424	axon
GO:0043025	neuronal cell body
GO:0043679	axon terminus
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome