InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTDSP1

Summary

InnateDB Protein

IDBP-80991.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTDSP1

Protein Name

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000273062

InnateDB Gene

IDBG-80989 (CTDSP1)

Protein Structure

UniProt Annotation

Function

Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. {ECO:0000269PubMed:12721286, ECO:0000269PubMed:15681389}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12721286}. Note=Colocalizes with RNA polymerase II.

Disease Associations

Tissue Specificity

Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta. {ECO:0000269PubMed:15681389}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	8 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008420	CTD phosphatase activity
GO:0016791	phosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006470	protein dephosphorylation
GO:0045665	negative regulation of neuron differentiation
GO:0050768	negative regulation of neurogenesis