InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNNT1

Summary

InnateDB Protein

IDBP-70166.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNNT1

Protein Name

troponin T type 1 (skeletal, slow)

Synonyms

ANM; NEM5; STNT; TNT; TNTS;

Species

Homo sapiens

Ensembl Protein

ENSP00000349233

InnateDB Gene

IDBG-70162 (TNNT1)

Protein Structure

UniProt Annotation

Function

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Subcellular Localization

Disease Associations

Nemaline myopathy 5 (NEM5) [MIM:605355]: A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Nemaline myopathy type 5 is a severe and progressive form common among Old Order Amish. Affected infants display tremors with hypotonia and mild contractures of the shoulders and hips. Proximal contractures progressively weaken and a pectus carinatum deformity develops before children die of respiratory insufficiency, usually in the second year. {ECO:0000269PubMed:10952871}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.

Experimentally validated
Total	89 [view]
Protein-Protein	89 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005523	tropomyosin binding

Biological Process

GO:0003009	skeletal muscle contraction
GO:0006937	regulation of muscle contraction
GO:0030049	muscle filament sliding
GO:0045932	negative regulation of muscle contraction