InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MC1R

Summary

InnateDB Protein

IDBP-699999.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MC1R

Protein Name

Melanocyte-stimulating hormone receptor

Synonyms

MC1-R; MSHR;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000055607

InnateDB Gene

IDBG-647150 (MC1R)

Protein Structure

UniProt Annotation

Function

Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Could be involved in spermatogenesis.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in the testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004977	melanocortin receptor activity
GO:0004980	melanocyte-stimulating hormone receptor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010739	positive regulation of protein kinase A signaling
GO:0019233	sensory perception of pain
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032720	negative regulation of tumor necrosis factor production
GO:0035556	intracellular signal transduction
GO:0042438	melanin biosynthetic process
GO:0043473	pigmentation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051897	positive regulation of protein kinase B signaling
GO:0070914	UV-damage excision repair
GO:0090037	positive regulation of protein kinase C signaling

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000761 Melanocyte-stimulating hormone receptor
IPR001671 Melanocortin/ACTH receptor
IPR001908 Melanocortin receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00536
PR00534
PR00535

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P47798