InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HMGCR

Summary

InnateDB Protein

IDBP-697761.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMGCR

Protein Name

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

Synonyms

hmg-coa-r;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000010315

InnateDB Gene

IDBG-645081 (HMGCR)

Protein Structure

UniProt Annotation

Function

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005515	protein binding
GO:0008158	hedgehog receptor activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042282	hydroxymethylglutaryl-CoA reductase activity
GO:0050661	NADP binding
GO:0050662	coenzyme binding
GO:0070402	NADPH binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006694	steroid biosynthetic process
GO:0006695	cholesterol biosynthetic process
GO:0008202	steroid metabolic process
GO:0008203	cholesterol metabolic process
GO:0008299	isoprenoid biosynthetic process
GO:0008542	visual learning
GO:0015936	coenzyme A metabolic process
GO:0016126	sterol biosynthetic process
GO:0043407	negative regulation of MAP kinase activity
GO:0051262	protein tetramerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000731 Sterol-sensing domain
IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II
IPR003392 Patched
IPR004554 Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type
IPR004816 Hydroxymethylglutaryl-CoA reductase, metazoan
IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain

PFAM

PF00368
PF02460

PRINTS

PR00071

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A7Z064