Version 5.4
Bos taurus Protein: TNNT1
Summary
InnateDB Protein IDBP-694350.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNNT1
Protein Name Troponin T, slow skeletal muscle
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008420
InnateDB Gene IDBG-641928 (TNNT1)
Protein Structure
UniProt Annotation
Function Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed dominantly in slow muscles, like masseter, diaphragm, psoas major and spinnalis. Isoform 2 is also expressed in fast muscles. {ECO:0000269PubMed:12772845}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005523 tropomyosin binding
Biological Process
GO:0003009 skeletal muscle contraction
GO:0006937 regulation of muscle contraction
GO:0045932 negative regulation of muscle contraction
Cellular Component
GO:0005861 troponin complex
Protein Structure and Domains
PDB ID
InterPro IPR001978 Troponin
PFAM PF00992
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8MKH6
PhosphoSite PhosphoSite-
TrEMBL B1GVZ4
UniProt Splice Variant
Entrez Gene 282095
UniGene
RefSeq NP_776899
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB085600 AB085601 AM930546 AM930555 BC118248
GenPept AAI18249 BAB92983 BAB92984 CAP59627 CAP59635

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca