InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hmgcr

Summary

InnateDB Protein

IDBP-623977.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmgcr

Protein Name

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

Synonyms

HMG-CoAR; Red;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126959

InnateDB Gene

IDBG-174808 (Hmgcr)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0050662	coenzyme binding

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0008542	visual learning
GO:0015936	coenzyme A metabolic process
GO:0043407	negative regulation of MAP kinase activity
GO:0055114	oxidation-reduction process

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:96159

InterPro

IPR000731 Sterol-sensing domain

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q61671

UniProt Splice Variant

Entrez Gene

15357

UniGene

Mm.489666

RefSeq

MGI ID

MGI Symbol

Hmgcr

OMIM

CCDS

HPRD

IMGT

EMBL

AC154851 X07888

GenPept

CAA30734