Version 5.4
Mus musculus Protein: Hmgcr
Summary
InnateDB Protein IDBP-623976.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hmgcr
Protein Name 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Synonyms HMG-CoAR; Red;
Species Mus musculus
Ensembl Protein ENSMUSP00000128294
InnateDB Gene IDBG-174808 (Hmgcr)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0042282 hydroxymethylglutaryl-CoA reductase activity
GO:0042803 protein homodimerization activity
GO:0070402 NADPH binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0006743 ubiquinone metabolic process
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008299 isoprenoid biosynthetic process
GO:0008542 visual learning
GO:0010664 negative regulation of striated muscle cell apoptotic process
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0015936 coenzyme A metabolic process
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0043407 negative regulation of MAP kinase activity
GO:0045445 myoblast differentiation
GO:0045471 response to ethanol
GO:0045908 negative regulation of vasodilation
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051262 protein tetramerization
GO:0055114 oxidation-reduction process
GO:0061045 negative regulation of wound healing
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:96159
InterPro IPR000731 Sterol-sensing domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q61671
UniProt Splice Variant
Entrez Gene 15357
UniGene Mm.489666
RefSeq
MGI ID
MGI Symbol Hmgcr
OMIM
CCDS
HPRD
IMGT
EMBL AC154851 X07888
GenPept CAA30734

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca