InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hmgcr

Summary

InnateDB Protein

IDBP-623974.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmgcr

Protein Name

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

Synonyms

HMG-CoAR; Red;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132155

InnateDB Gene

IDBG-174808 (Hmgcr)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050662	coenzyme binding

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0008542	visual learning
GO:0015936	coenzyme A metabolic process
GO:0043407	negative regulation of MAP kinase activity
GO:0055114	oxidation-reduction process

Cellular Component

Protein Structure and Domains

PDB ID

MGI:96159

InterPro

IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II
IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding
IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding

PFAM

PF00368

PRINTS

PR00071

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite