InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc29a1

Summary

InnateDB Protein

IDBP-623468.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc29a1

Protein Name

solute carrier family 29 (nucleoside transporters), member 1

Synonyms

1200014D21Rik; AA407560; ENT1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000131976

InnateDB Gene

IDBG-185538 (Slc29a1)

Protein Structure

UniProt Annotation

Function

Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs).

Subcellular Localization

Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Predominantly localized in the basolateral membrane in polarized MDCK cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in heart, spleen, lung, liver and testis. Lower level of expression in brain and kidney. {ECO:0000269PubMed:11027664}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005337	nucleoside transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0007595	lactation
GO:0015858	nucleoside transport
GO:0015862	uridine transport
GO:0030431	sleep
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0071333	cellular response to glucose stimulus
GO:0071456	cellular response to hypoxia
GO:1901642	nucleoside transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane