InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUSP2

Summary

InnateDB Protein

IDBP-61500.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUSP2

Protein Name

dual specificity phosphatase 2

Synonyms

PAC-1; PAC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000288943

InnateDB Gene

IDBG-61498 (DUSP2)

Protein Structure

UniProt Annotation

Function

Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in hematopoietic tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0008330	protein tyrosine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0051019	mitogen-activated protein kinase binding

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0001706	endoderm formation
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001763 Rhodanese-like domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782
PF00581

PRINTS

PR00700
PR01764

PIRSF

PIRSF000939

SMART

SM00194
SM00450
SM00404
SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References