InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNTB2

Summary

InnateDB Protein

IDBP-600587.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNTB2

Protein Name

syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)

Synonyms

D16S2531E; EST25263; SNT2B2; SNT3; SNTL;

Species

Homo sapiens

Ensembl Protein

ENSP00000436443

InnateDB Gene

IDBG-38937 (SNTB2)

Protein Structure

UniProt Annotation

Function

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.

Subcellular Localization

Membrane. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cell junction {ECO:0000250}. Cytoplasm, cytoskeleton. Note=Membrane-associated. In muscle, it is exclusively localized at the neuromuscular junction (By similarity). In insulinoma cell line, it is enriched in secretory granules. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0044822	poly(A) RNA binding

Biological Process

Cellular Component

GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0016010	dystrophin-associated glycoprotein complex
GO:0016020	membrane
GO:0030054	cell junction
GO:0030658	transport vesicle membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome