Version 5.4
Homo sapiens Protein: MSL2
Summary
InnateDB Protein IDBP-57825.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSL2
Protein Name male-specific lethal 2 homolog (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000311827
InnateDB Gene IDBG-57823 (MSL2)
Protein Structure
UniProt Annotation
Function Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. {ECO:0000269PubMed:21726816}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0006325 chromatin organization
GO:0043984 histone H4-K16 acetylation
Cellular Component
GO:0005654 nucleoplasm
GO:0072487 MSL complex
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
PFAM PF13639
PF14634
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HCI7
PhosphoSite PhosphoSite-Q9HCI7
TrEMBL C9J5S2
UniProt Splice Variant
Entrez Gene 55167
UniGene Hs.606332
RefSeq NP_060603
HUGO HGNC:25544
OMIM 614802
CCDS CCDS33861
HPRD 08550
IMGT
EMBL AB046805 AC092991 AK001408 AK302491 AL834289 BC032719 BC093764 BC093790 CH471052
GenPept AAH32719 AAH93764 AAH93790 BAA91673 BAB13411 BAG63776 CAD38963 EAW79119 EAW79120

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca