Version 5.4
Mus musculus Protein: Hsd11b1
Summary
InnateDB Protein IDBP-540346.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hsd11b1
Protein Name hydroxysteroid 11-beta dehydrogenase 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000125620
InnateDB Gene IDBG-209137 (Hsd11b1)
Protein Structure
UniProt Annotation
Function Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.
Subcellular Localization Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Disease Associations
Tissue Specificity Widely expressed. Highest expression in liver.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
GO:0016491 oxidoreductase activity
GO:0070524 11-beta-hydroxysteroid dehydrogenase (NADP+) activity
Biological Process
GO:0008152 metabolic process
GO:0008202 steroid metabolic process
GO:0030324 lung development
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:103562
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR013968 Polyketide synthase, KR
PFAM PF00106
PF08659
PRINTS PR00080
PR00081
PIRSF PIRSF000126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P50172
PhosphoSite PhosphoSite-P50172
TrEMBL Q4JHD9
UniProt Splice Variant
Entrez Gene 15483
UniGene Mm.438606
RefSeq NP_032314
MGI ID 4NMH
MGI Symbol Hsd11b1
OMIM
CCDS CCDS15635
HPRD
IMGT
EMBL AC022675 AK149518 AK167419 AL365322 BC132364 BC138780 BC145415 DQ089001 S75207 X83202 X92186
GenPept AAB33601 AAI32365 AAI38781 AAI45416 AAY98349 BAE28932 BAE39507 CAA58209 CAA63096

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca