Version 5.4
Mus musculus Protein: Top2b
Summary
InnateDB Protein IDBP-536965.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Top2b
Protein Name topoisomerase (DNA) II beta
Synonyms D230016L12Rik; Top-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000123789
InnateDB Gene IDBG-133323 (Top2b)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity
GO:0005524 ATP binding
GO:0008301 DNA binding, bending
Biological Process
GO:0000712 resolution of meiotic recombination intermediates
GO:0000819 sister chromatid segregation
GO:0001764 neuron migration
GO:0006200 ATP catabolic process
GO:0006265 DNA topological change
GO:0006268 DNA unwinding involved in DNA replication
GO:0006312 mitotic recombination
GO:0007409 axonogenesis
GO:0030900 forebrain development
GO:0044774 mitotic DNA integrity checkpoint
Cellular Component
GO:0005634 nucleus
GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)
Protein Structure and Domains
PDB ID MGI:98791
InterPro IPR001154 DNA topoisomerase II, eukaryotic-type
IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal
IPR013760 DNA topoisomerase, type IIA-like domain
PFAM PF00521
PRINTS PR01158
PIRSF
SMART SM00434
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F6V2E8
UniProt Splice Variant
Entrez Gene 21974
UniGene Mm.404738
RefSeq
MGI ID
MGI Symbol Top2b
OMIM
CCDS
HPRD
IMGT
EMBL AC154452 AC154471
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca