Version 5.4
Mus musculus Protein: Nox1
Summary
InnateDB Protein IDBP-536500.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nox1
Protein Name NADPH oxidase 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000124225
InnateDB Gene IDBG-170699 (Nox1)
Protein Structure
UniProt Annotation
Function Pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism. {ECO:0000269PubMed:16724959}.
Subcellular Localization Cell projection, invadopodium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 2 expressed in colon and vascular smooth muscle cells (VSMC). {ECO:0000269PubMed:16724959}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016175 superoxide-generating NADPH oxidase activity
GO:0030171 voltage-gated proton channel activity
GO:0046872 metal ion binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0001525 angiogenesis
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin
GO:0008284 positive regulation of cell proliferation
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0015992 proton transport
GO:0016477 cell migration
GO:0030198 extracellular matrix organization
GO:0042554 superoxide anion generation
GO:0042743 hydrogen peroxide metabolic process
GO:0043410 positive regulation of MAPK cascade
GO:0045087 innate immune response (InnateDB)
GO:0045726 positive regulation of integrin biosynthetic process
GO:0046330 positive regulation of JNK cascade
GO:0051454 intracellular pH elevation
GO:0055114 oxidation-reduction process
GO:0071455 cellular response to hyperoxia
GO:0071468 cellular response to acidity
GO:0072592 oxygen metabolic process
GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0030054 cell junction
GO:0043020 NADPH oxidase complex
GO:0071438 invadopodium membrane
Protein Structure and Domains
PDB ID MGI:2450016
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CIZ9
PhosphoSite PhosphoSite-Q8CIZ9
TrEMBL
UniProt Splice Variant
Entrez Gene 237038
UniGene Mm.455133
RefSeq
MGI ID
MGI Symbol Nox1
OMIM
CCDS
HPRD
IMGT
EMBL AB206383 AB206384 AB206385 AF539799 AK136432 AL671915 AY174116
GenPept AAN75144 AAO20852 BAE22974 BAF03561 BAF03562 BAF03563 CAM16733 CAM16734

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca