InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Asb8

Summary

InnateDB Protein

IDBP-535097.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Asb8

Protein Name

ankyrin repeat and SOCS box-containing 8

Synonyms

4930539L19Rik; AI788835; C430011H06Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119481

InnateDB Gene

IDBG-180093 (Asb8)

Protein Structure

UniProt Annotation

Function

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0008150	biological_process
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1925791

InterPro

IPR001496 SOCS protein, C-terminal
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain

PFAM

PF07525
PF00023
PF13606
PF11929
PF12796

PRINTS

PR01415

PIRSF

SMART

SM00253
SM00969
SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91ZT9

PhosphoSite

PhosphoSite-Q91ZT9

TrEMBL

UniProt Splice Variant

Entrez Gene

78541

UniGene

Mm.416117

RefSeq

MGI ID

MGI Symbol

Asb8

OMIM

CCDS

CCDS27787

HPRD

IMGT

EMBL

AF398969 BC025106

GenPept

AAH25106 AAK97491