InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tpk1

Summary

InnateDB Protein

IDBP-533368.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tpk1

Protein Name

thiamine pyrophosphokinase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121115

InnateDB Gene

IDBG-143263 (Tpk1)

Protein Structure

UniProt Annotation

Function

Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. {ECO:0000269PubMed:10567383, ECO:0000269PubMed:16365036}.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in kidney and liver, and at lower levels in heart, brain and testis. {ECO:0000269PubMed:10567383}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004788	thiamine diphosphokinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity

Biological Process

GO:0006772	thiamine metabolic process
GO:0009229	thiamine diphosphate biosynthetic process
GO:0016310	phosphorylation

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1352500

InterPro

IPR007371 Thiamin pyrophosphokinase, catalytic domain

PFAM

PF04263

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9R0M5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

29807

UniGene

Mm.403757

RefSeq

MGI ID

2F17

MGI Symbol

Tpk1

OMIM

CCDS

HPRD

IMGT

EMBL

AB027568 AK028431 AK035044 AK039131 AK136486 BC015246 BC023354

GenPept

AAH15246 AAH23354 BAA87040 BAC25948 BAC28923 BAC30248 BAE23001