Version 5.4
Mus musculus Protein: Ap1s3
Summary
InnateDB Protein IDBP-531808.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ap1s3
Protein Name adaptor-related protein complex AP-1, sigma 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000125268
InnateDB Gene IDBG-172884 (Ap1s3)
Protein Structure
UniProt Annotation
Function Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008565 protein transporter activity
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0005905 coated pit
GO:0030117 membrane coat
GO:0030659 cytoplasmic vesicle membrane
Protein Structure and Domains
PDB ID MGI:1891304
InterPro IPR011012 Longin-like domain
IPR016635 Adaptor protein complex, sigma subunit
IPR022775 AP complex, mu/sigma subunit
PFAM PF01217
PRINTS
PIRSF PIRSF015588
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TN05
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 252903
UniGene Mm.32409
RefSeq NP_898848
MGI ID
MGI Symbol Ap1s3
OMIM
CCDS CCDS35628
HPRD
IMGT
EMBL BC054111 BC098237
GenPept AAH54111 AAH98237

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca