InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DEPDC1

Summary

InnateDB Protein

IDBP-385707.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DEPDC1

Protein Name

DEP domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000412292

InnateDB Gene

IDBG-99608 (DEPDC1)

Protein Structure

UniProt Annotation

Function

May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. {ECO:0000269PubMed:20587513}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17452976, ECO:0000269PubMed:20587513}. Note=Colocalizes with ZNF224 at the nucleus.

Disease Associations

Tissue Specificity

Expressed in testis. Up-regulated in bladder cancer cells (at protein level). {ECO:0000269PubMed:17452976}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007165	signal transduction
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0045892	negative regulation of transcription, DNA-templated