Version 5.4
Homo sapiens Protein: WDR82
Summary
InnateDB Protein IDBP-38542.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDR82
Protein Name WD repeat domain 82
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000296490
InnateDB Gene IDBG-38540 (WDR82)
Protein Structure
UniProt Annotation
Function Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. {ECO:0000269PubMed:17998332, ECO:0000269PubMed:18838538, ECO:0000269PubMed:20516061}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16253997, ECO:0000269PubMed:17355966, ECO:0000269PubMed:20516061}. Note=Associates with chromatin.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
Experimentally validated
Total 62 [view]
Protein-Protein 62 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
Biological Process
GO:0051568 histone H3-K4 methylation
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0035097 histone methyltransferase complex
GO:0048188 Set1C/COMPASS complex
GO:0072357 PTW/PP1 phosphatase complex
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UXN9
PhosphoSite PhosphoSite-Q6UXN9
TrEMBL C9JBU3
UniProt Splice Variant
Entrez Gene 80335
UniGene Hs.717997
RefSeq NP_079498
HUGO HGNC:28826
OMIM 611059
CCDS CCDS2851
HPRD 15183
IMGT
EMBL AC092045 AK074290 AK291380 AY358264 CH471055
GenPept AAQ88631 BAB85039 BAF84069 EAW65202 EAW65203

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca