Version 5.4
Homo sapiens Protein: MUC3A
Summary
InnateDB Protein IDBP-384070.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MUC3A
Protein Name mucin 3A, cell surface associated
Synonyms MUC-3A; MUC3;
Species Homo sapiens
Ensembl Protein ENSP00000393306
InnateDB Gene IDBG-32641 (MUC3A)
Protein Structure
UniProt Annotation
Function Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling. {ECO:0000269PubMed:10405327}.
Subcellular Localization Isoform 1: Membrane; Single-pass membrane protein.Isoform 2: Secreted.Isoform 3: Secreted.Isoform 4: Secreted.Isoform 5: Secreted.
Disease Associations
Tissue Specificity Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder. {ECO:0000269PubMed:11289722}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
GO:0005515 protein binding
GO:0030197 extracellular matrix constituent, lubricant activity
Biological Process
GO:0016266 O-glycan processing
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005796 Golgi lumen
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000742 Epidermal growth factor-like domain
PFAM PF00008
PRINTS
PIRSF
SMART SM00181
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q02505
PhosphoSite PhosphoSite-Q02505
TrEMBL Q7LDU4
UniProt Splice Variant
Entrez Gene 4584
UniGene Hs.727333
RefSeq XP_003846779
HUGO HGNC:7513
OMIM 158371
CCDS
HPRD
IMGT
EMBL AB038782 AC105446 AC118759 AF007190 AF007193 AF007194 AF007196 AF113616 AF143371 AF143372 AF143373 AY307930 JQ511939 M55405 M55406
GenPept AAA63772 AAA63773 AAB84383 AAC02268 AAC02271 AAC02272 AAD45882 AAD45883 AAD45884 AAF13032 AAQ73824 AFG72974 BAB12116

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca