InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEC16A

Summary

InnateDB Protein

IDBP-384008.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEC16A

Protein Name

SEC16 homolog A (S. cerevisiae)

Synonyms

KIAA0310; p250; SEC16L;

Species

Homo sapiens

Ensembl Protein

ENSP00000387583

InnateDB Gene

IDBG-92412 (SEC16A)

Protein Structure

UniProt Annotation

Function

Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization. {ECO:0000269PubMed:17005010, ECO:0000269PubMed:17192411}.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=SAR1A activity is required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation.

Disease Associations

Tissue Specificity

Ubiquitous. Expressed at higher levels in the pancreas. {ECO:0000269PubMed:17192411}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007029	endoplasmic reticulum organization
GO:0015031	protein transport
GO:0021762	substantia nigra development
GO:0048208	COPII vesicle coating

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O15027

PhosphoSite

PhosphoSite-O15027

TrEMBL

UniProt Splice Variant

Entrez Gene

9919

UniGene

Hs.602836

RefSeq

HUGO

HGNC:29006

OMIM

612854

CCDS

HPRD

IMGT

EMBL

AB002308 AL592301 BC008332 BC028183 BC098454 DQ903855

GenPept

AAH08332 AAH28183 AAH98454 ABI78944 BAA20769 CAI13949 CAI13951 CAI13952