InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TOP2B

Summary

InnateDB Protein

IDBP-368167.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TOP2B

Protein Name

topoisomerase (DNA) II beta 180kDa

Synonyms

top2beta; TOPIIB;

Species

Homo sapiens

Ensembl Protein

ENSP00000391112

InnateDB Gene

IDBG-22611 (TOP2B)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	59 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity
GO:0005524	ATP binding
GO:0008301	DNA binding, bending

Biological Process

GO:0006200	ATP catabolic process
GO:0006265	DNA topological change

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR001154 DNA topoisomerase II, eukaryotic-type
IPR001241 DNA topoisomerase, type IIA
IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal
IPR003594 Histidine kinase-like ATPase, C-terminal domain
IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2
IPR013760 DNA topoisomerase, type IIA-like domain
IPR020568 Ribosomal protein S5 domain 2-type fold

PFAM

PF00521
PF02518
PF13581
PF00204

PRINTS

PR01158
PR00418

PIRSF

SMART

SM00433
SM00434
SM00387

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt