InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Depdc1a

Summary

InnateDB Protein

IDBP-269586.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Depdc1a

Protein Name

DEP domain containing 1a

Synonyms

5830484J08Rik; Depdc1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101656

InnateDB Gene

IDBG-201387 (Depdc1a)

Protein Structure

UniProt Annotation

Function

May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Colocalizes with ZNF224 at the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007165	signal transduction
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0045892	negative regulation of transcription, DNA-templated