InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Idh2

Summary

InnateDB Protein

IDBP-266783.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Idh2

Protein Name

isocitrate dehydrogenase 2 (NADP+), mitochondrial

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103007

InnateDB Gene

IDBG-194560 (Idh2)

Protein Structure

UniProt Annotation

Function

Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Heart > kidney >> other tissues. {ECO:0000269PubMed:11278619}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004450	isocitrate dehydrogenase (NADP+) activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287	NAD binding

Biological Process

GO:0006097	glyoxylate cycle
GO:0006099	tricarboxylic acid cycle
GO:0006102	isocitrate metabolic process
GO:0006103	2-oxoglutarate metabolic process
GO:0006950	response to stress
GO:0055114	oxidation-reduction process