InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccbl1

Summary

InnateDB Protein

IDBP-253404.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccbl1

Protein Name

cysteine conjugate-beta lyase 1

Synonyms

2010009K05Rik; AI182306; Gtk; Kat1; KatI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109292

InnateDB Gene

IDBG-155774 (Ccbl1)

Protein Structure

UniProt Annotation

Function

Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016212	kynurenine-oxoglutarate transaminase activity
GO:0030170	pyridoxal phosphate binding
GO:0042803	protein homodimerization activity
GO:0047312	L-phenylalanine:pyruvate aminotransferase activity
GO:0047316	glutamine-phenylpyruvate transaminase activity
GO:0047804	cysteine-S-conjugate beta-lyase activity
GO:0047945	L-glutamine:pyruvate aminotransferase activity