InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACP1

Summary

InnateDB Protein

IDBP-25065.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACP1

Protein Name

acid phosphatase 1, soluble

Synonyms

HAAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000272065

InnateDB Gene

IDBG-25059 (ACP1)

Protein Structure

UniProt Annotation

Function

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

T-lymphocytes express only isoform 2. {ECO:0000269PubMed:9038134}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003993	acid phosphatase activity
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity
GO:0005515	protein binding

Biological Process

GO:0035335

peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0009898	cytoplasmic side of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000106 Protein-tyrosine phosphatase/arsenate reductase
IPR002115 Protein-tyrosine phosphatase, low molecular weight, mammalian
IPR023485 Phosphotyrosine protein phosphatase I superfamily

PFAM

PF01451

PRINTS

PR00719
PR00720

PIRSF

SMART

SM00226

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt