InnateDB Protein
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IDBP-245040.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TANK
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Protein Name
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TRAF family member-associated NFKB activator
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Synonyms
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I-TRAF; ITRAF; TRAF2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000376505
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InnateDB Gene
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IDBG-73552 (TANK)
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Protein Structure
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Function |
Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269PubMed:12133833, ECO:0000269PubMed:21931631}.
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Subcellular Localization |
Cytoplasm.
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Disease Associations |
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated |
Total |
85
[view]
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Protein-Protein |
85
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
14 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q92844
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PhosphoSite |
PhosphoSite-Q92844
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TrEMBL |
Q53TI5
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UniProt Splice Variant |
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Entrez Gene |
10010
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UniGene |
Hs.715913
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RefSeq |
NP_001186064
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HUGO |
HGNC:11562
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OMIM |
603893
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CCDS |
CCDS2215
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HPRD |
04870
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IMGT |
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EMBL |
AC009299
AC009313
BC003388
BT009855
CH471058
U59863
U63830
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GenPept |
AAC50681
AAC50770
AAH03388
AAP88857
AAX88939
AAY14785
EAX11374
EAX11375
EAX11377
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