Version 5.4
Homo sapiens Protein: ACP6
Summary
InnateDB Protein IDBP-244532.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACP6
Protein Name acid phosphatase 6, lysophosphatidic
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000376714
InnateDB Gene IDBG-101834 (ACP6)
Protein Structure
UniProt Annotation
Function Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid. {ECO:0000269PubMed:10506173, ECO:0000269PubMed:23807634}.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:10506173}.
Disease Associations
Tissue Specificity Highly expressed in kidney, heart, small intestine, muscle, liver, prostate, testis, ovary and weakly expressed in thymus and colon. {ECO:0000269PubMed:10506173, ECO:0000269PubMed:12010880}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003993 acid phosphatase activity
GO:0052642 lysophosphatidic acid phosphatase activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0016311 dephosphorylation
GO:2001311 lysobisphosphatidic acid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR000560 Histidine phosphatase superfamily, clade-2
IPR029033 Histidine phosphatase superfamily
PFAM PF00328
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NPH0
PhosphoSite PhosphoSite-Q9NPH0
TrEMBL
UniProt Splice Variant
Entrez Gene 51205
UniGene
RefSeq XP_006711427
HUGO HGNC:29609
OMIM 611471
CCDS
HPRD 16472
IMGT
EMBL AB030039 AB031478 AB209248 AK000657 AL359207 AY358552 BC009965 BC034686 CR457101
GenPept AAH09965 AAH34686 AAQ88916 BAA89311 BAA91310 BAA94309 BAD92485 CAG33382 CAI15199

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca