InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CORO1B

Summary

InnateDB Protein

IDBP-242686.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CORO1B

Protein Name

coronin, actin binding protein, 1B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000377471

InnateDB Gene

IDBG-60380 (CORO1B)

Protein Structure

UniProt Annotation

Function

Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:16027158}. Note=Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	28 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0051015	actin filament binding
GO:0071933	Arp2/3 complex binding

Biological Process

GO:0016477	cell migration
GO:0030036	actin cytoskeleton organization
GO:0031529	ruffle organization
GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation
GO:0035767	endothelial cell chemotaxis
GO:0042060	wound healing
GO:0051017	actin filament bundle assembly
GO:0090135	actin filament branching
GO:1902463	protein localization to cell leading edge
GO:2000394	positive regulation of lamellipodium morphogenesis

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005884	actin filament
GO:0015629	actin cytoskeleton
GO:0030027	lamellipodium
GO:0031252	cell leading edge
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR015048 Domain of unknown function DUF1899
IPR015049 Domain of unknown function DUF1900
IPR017986 WD40-repeat-containing domain

PFAM

PF00400
PF08953
PF08954

PRINTS

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BR76